Friday, August 3, 2012

Germany handed team sprint gold as China relegated

Germany's Miriam Welte and Kristina Vogel were crowned inaugural Olympic women's team sprint champions in controversial fashion following the relegation of China at the Velodrome Thursday.

Guo Shuang and Gong Jinjie had combined to claim what would have been an historic first Olympic cycling gold for China in the two-lap event, only to be relegated soon after for a slight infringement in the changeover zone.

It meant China -- who had smashed the world record twice on their way to the final -- were relegated to the silver medal position, with Australia, who beat Ukraine in the battle for third place, winning the bronze.

"We really could not believe it when we saw it on the screen that we were Olympic champions. It's amazing. It's weird and amazing," said Vogel.

"We couldn't believe it when the Chinese girls were relegated, just like the GB girls, I was thinking, 'what's going on here?'" said Welte.

"I still can't believe it, but it feels very good to be the Olympic champions!"

Guo and Gong were not the only pair to fall foul of the rules as the women's event event made its Olympic debut.

Earlier, Olympic and six-time world sprint champion Victoria Pendleton and Jess Varnish were relegated from the first round for an "irregular change".

Pendleton and Varnish had signalled their gold medal intentions by beating Welte and Vogel's world record of 32.549sec, set by the German pair last April, to qualify for the gold medal match with China.

But despite protests from British cycling's team chief Dave Brailsford, they were relegated from the first round.

The setback ended Pendleton's bid for three gold medals at the Games, in which she is also competing in the sprint and keirin.

"It's just one of those things that happened. We were probably just a bit too eager and excited for a ride," said a distraught Pendleton.

"Now and again rubbish things happen and this is one of those. The only positives I can take is I know I'm in good form."

Guo, China's main hope for gold in the sprint and keirin, and Gong looked devastated on hearing the news. However they returned to the podium for the medal ceremony, smiling as they collected their silvers.

The pair had earlier underlined their gold medal credentials by twice setting a new world record for the two-lap power event in 32.447 and 32.442.

Winning the bronze meant Australian Anna Meares' hopes for three gold medals in London went up in smoke.

Meares, who is regarded as Pendleton's biggest challenger in the sprint and keirin events, had posted the fastest opening lap in the first round only for partner Kaarle McCulloch to perform short of expectations.

"You can't go down that path. That's what we had, that's what we did, that's what we got," said Meares.

"We probably benefited a little bit from the British being disqualified. I can only imagine how devastating that was for them. It was bittersweet for Kaarle and I," she said.

Source: http://news.yahoo.com/china-set-second-world-record-team-sprint-162037283.html

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Thursday, August 2, 2012

'Own your own boda' (motorcycle taxi) empowers Ugandans

A startup helps motorcycle taxi drivers in Kampala, Uganda, buy their bikes, which in turn helps them buy homes, start businesses, and send their kids to school.

By Rachel Cernansky,?Contributor / August 1, 2012

Motorcycle taxis, or boda bodas, are Kampala, Uganda's equivalent of rickshaws in India or yellow cabs in New York.

Courtesy of Edward Echwalu

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To get around Kampala, the capital of Uganda, you might find yourself on the back of a motorcycle.

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Motorcycle taxis, or boda bodas, are that East African city's equivalent of rickshaws in India or yellow cabs in New York. But boda boda drivers, however sharply they're dressed,? often barely make ends meet: A big chunk of most drivers' incomes goes toward rent payments to the motorcycle owner.

For a growing number of boda boda drivers, however, that loss of income has stopped: Instead of paying 50,000?shillings ($20) a week in rent for the motorcycle, they pay 60,000 shillings ($24) a week for 17 or 18 months to become full-fledged owners of their own bikes.

Own Your Own Boda (OYOB) is a young enterprise that aims to profit by empowering people to earn more income and be less dependent on an owner who can take the bike away at any time. OYOB reinvests its profits into buy more motorcycles and expanding the program to other drivers ? and perhaps eventually to other cities.

To date, OYOB has loaned out about 70 motorcycles, most of which are on the road now (25 loans are already completed). Another 20 to 30 people are on the waiting list.

Co-founder and CEO Michael Wilkerson says that once the driver owns his own motorcycle, he takes home about $100 extra per month. Drivers have used that extra income to buy homes, start new businesses, and pay school fees for their children.

OYOB was founded by Mr. Wilkerson and a friend he met while working at The Independent news magazine in Uganda, Matt Brown. The enterprise came into being almost by accident. Medie Sebi, who is now the company's manager, was a boda boda driver in Kampala whom Wilkerson trusted and had befriended. Mr. Sebi managed to get a boda boda loan, and when he took ownership of the motorbike, he was able to sell it and buy land for his mother.

"Medie took me to have lunch with his mother, in her village on the land that he bought, in the small one-room brick house, which he also helped build," Wilkerson says.

He was impressed. So Wilkerson and Mr. Brown asked Sebi if he'd want another loan; they wanted to try out administering such a loan, and they trusted Sebi as a starting point. He said yes ? and pointed out that many others like him needed the same kind of help.

Soon enough, Wilkerson and Brown had loaned out seven bikes. Ugandan journalist Andrew Mwenda, who founded The Independent, took notice. "I'll never forget the words he used," Wilkerson says. "'You are changing the trajectory of these people's lives.'"

Mr. Mwenda is not one to support just any old development program. Interested in seeing the positive impact scaled up, he invested the project. It's been growing ever since.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/56HjaohGKdQ/Own-your-own-boda-motorcycle-taxi-empowers-Ugandans

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What A Tea Party Candidate's Win Means For Washington

By MICHAEL FALCONE ( @michaelpfalcone ), CHRIS GOOD ( @c_good ) and ELIZABETH HARTFIELD ( @LizHartfield )

NOTABLES:

VEEP DAY DRAWS NEAR: Mitt Romney's campaign won't say anything about when a vice presidential announcement will be made, but here is a hint: ABC's Jonathan Karl reports that two potential candidates who have been told to stand ready for an announcement any day now that Romney has returned from his foreign trip. The messages were delivered before Romney returned. The candidates were told to be prepared to jump into action anytime after the end of the trip. Only Romney ultimately knows when he will pull the trigger, but the widespread expectation of those close to him is that it will happen well before the Republican convention - although likely not before next week. As for who the pick will be, Karl notes that the shortened short list comes down to three names: Ohio Sen. Rob Portman, former Minnesota Gov. Tim Pawlenty and Wisconsin Rep. Paul Ryan. WATCH Jon Karl's "Good Morning America" report on veepstakes: http://abcn.ws/NIRiSY

FUELING THE SPECULATION: Romney is back in the U.S. after an international trip plagued with gaffes, and at an event tomorrow in Colorado, he will share the stage with a number of Republican governors and veep potentials, ABC's Arlette Saenz notes. Romney will appear with Governors Chris Christie and Bob McDonnell and potentially others at the event in Basalt, Colo. NOTED: A number of potential running mates, including New Jersey Gov. Chris Christie, South Carolina Gov. Nikki Haley, Louisiana Gov. Bobby Jindal, Virginia Gov. Bob McDonnell, and New Mexico Gov. Susana Martinez head to Aspen today for the Republican Governors Association quarterly meeting and a few will participate at a conversation at the Aspen Institute.

OBAMA GETS A SUMMER BUMP: New polls from Quinnipiac/New York Times/CBS News give President Obama the lead over Romney in Pennsylvania (53 percent to 42 percent), Florida (51 percent to 45 percent), and Ohio (50 percent to 44 percent). The New York Times' Jeff Zeleny and Dalia Sussman write: "While independent voters break strongly for Mr. Obama in Pennsylvania, a state that Mr. Romney has been trying to make more competitive, they are closely split in Florida and Ohio. Of the coalition that Mr. Obama built to win the White House, independent voters remain a hurdle, with a little more than half in Florida and Ohio saying they disapprove of his job performance." http://nyti.ms/OCzJ7c

THE NOTE:

He's already being called the next Marco Rubio.

Conservative Republican Ted Cruz, who scored an upset - but rock-solid - victory over Lt. Gov. David Dewhurst in yesterday's Texas U.S. Senate runoff is being hailed today as the second coming of the current Florida senator and vice presidential short-lister.

"Just like the upstart Rubio, who started with long odds but defeated long time incumbent Florida Governor Charlie Christ in the 2010 GOP Primary with major support from the Tea Party, Cruz did exactly the same thing in Texas," the Christian Broadcasting Network's David Brody wrote in an analysis of last night's results. http://bit.ly/PokGJf

By Election Day, Cruz, a former Texas solicitor general, had already overtaken Dewhurst in recent polls. Cruz had the backing of Tea Party stalwarts like Sarah Palin and Sen. Jim DeMint whereas Dewhurst won the support of establishment figures like Texas Gov. Rick Perry, the erstwhile presidential hopeful.

As ABC's Elizabeth Hartfield points out, Cruz was also getting outspent. According to the Center for Responsive Politics, Dewhurst poured $11 million of his own personal fortune into his campaign, spending a total of $19 million, compared to the $7 million Cruz's campaign spent. http://abcn.ws/NI5w6B

So, what does one Republican's victory over a fellow GOPer in the bright red state of Texas mean in the grand scheme of things?

As Brody noted: "Eventually the media and others will realize that the Tea Party is not only far from dead it's just warming up."

But regardless of who wins control of the Senate this November, we know that the upper body in Washington is going to be as polarized and uncompromising as ever, notes ABC News Political Director Amy Walter. Conservative Republicans like Cruz and Richard Murdouck in Indiana won because they insisted they wouldn't be part of a "go along, get along" culture.

Ultimately, it also means that even if Romney is elected President he can't expect to win votes on "team spirit" alone.

To put it another way, as one smart Republican strategist told the Note: "The fact the Tea Party can win is the 2010 story; whether they can govern and what the 'establishment' will do to retool is the question."

SARAH PALIN SEND 'CONGRATS'. ABC's Shushannah Walshe points us toward Sarah Palin's Facebook page, which includes this note: "Congratulations to Ted Cruz! This is a victory both for Ted and for the grassroots Tea Party movement. This primary race has always been about the kind of leadership we need in D.C. Our goal is not just about changing the majority in the Senate. It is about the kind of leadership we want. Ted Cruz represents the kind of strong conservative leadership we want in D.C." http://on.fb.me/Pr4eb8

NOTE IT!

ABC's RICK KLEIN: Has a race ever had such wild shifts in momentum without the dynamics really changing at all? Now it's President Obama's turn on the upswing, coming off of a rough foreign trip for Mitt Romney and three battleground state polls that show Obama topping 50 percent. But lest you think anything is really different, the messaging is back to expected form. A new Obama ad accuses Romney policies of exploding the deficit; a new Romney ad blasts Obama over closed GM dealerships. So yes, those ads with the candidates looking to camera to lay out their visions won't be all we're seeing for the next three months.

NEW FROM ROMNEY H.Q. ABC's Arlette Saenz notes that Mitt Romney's campaign is out with a new ad hitting President Obama over the auto bailout this morning. The ad features a former auto dealership owner who lost his business during the bailout. WATCH: http://bit.ly/OnEFv

-The campaign also released this new web video hammering Obama over unemployment. "President Obama proudly proclaimed that his economic plan had 'worked.' Though with a decline in median household income and forty-one straight months of unemployment above eight percent, it's hard to see how it has been a success," according to a release accompanying the spot. WATCH: http://bit.ly/T2ll7F

-And while President Obama does not campaign in Florida until tomorrow, the Romney campaign has started the attacks in Florida with 13 large electronic billboards running today and tomorrow featuring real business owners upset with Obama's "You didn't build that" comment. The Tampa Bay Times reports on the campaign's billboard effort: http://bit.ly/OACwdD

Also, ABC's Gregory Simmons notes, this morning the Romney campaign is pushing an Op-Ed written by Ohio Sen. Rob Portman in the Akron Beacon Journal. The narrative Portman constructs is familiar: Obama thinks the government builds everything and is out of touch. Mitt Romney spent his life in the private sector and understands how to use government to create a business friendly environment. "By claiming that small business owners are not responsible for their own success, the president validates Washington's taxing them at the higher levels he is proposing to pay for an unprecedented level of federal spending," Portman writes. http://bit.ly/QoQ52h

ROMNEY WRAPS UP HIS JOURNEY OF GAFFES. With Mitt Romney returning from Europe, The Washington Post's Philip Rucker and Dan Balz write: "Romney flew home leaving two questions in his wake: Would the gaffes that dogged him abroad cause political damage at home, and did the trip speak to deeper problems in his campaign that could significantly hamper his hopes of winning in November? ? What he lacked was a strategy designed to draw attention to his role in turning around the 2002 Winter Olympics in Salt Lake City, which is generally regarded one of the highlights on his r?sum?. That left it to the British and American media to fill the vacuum with reports about his Olympics comments-which had some Republicans shaking their heads." http://wapo.st/OBm5O1

IN OHIO, OBAMA FLIES INTO AIRPORT CONTROVERSY. With President Obama traveling to Mansfield, Ohio today, ABC's Ann Compton reports: "If President Obama has his way, his Air Force One arrival would be one of the final flights into Mansfield-Lahm Airport," claims Sen. Rob Portman, who is often a surrogate campaigner in Ohio for Republican presidential candidate Mitt Romney. The Mansfield News Journal has run a series of stories and editorials expressing local worries that the air mission of the 179th Airlift Wing of the Ohio Air National Guard will end if proposed Pentagon budget cuts close it down. The local paper quotes Vice Commander Col. Michael Howard as saying he will park the wing's C-27J aircraft on the tarmac in full view of Air Force One to make a point to the visiting president. http://abcn.ws/MbtJMU

THE BUZZ:

with Chris Good ( @c_good)

NEW OBAMA AD: MITT ROMNEY, DEFICIT DRIVER. ABC's Devin Dwyer reports: President Obama has presided over three consecutive years of historically high federal budget deficits and the addition of more than $5 trillion to the national debt. Yet, in a new television ad for his re-election campaign, Obama casts himself as the only candidate for president with a plan to narrow the budget gap, while suggesting GOP rival Mitt Romney would make deficits worse. ? "You watched ? and worried. Two wars. Tax cuts for millionaires. Debt piled up," the narrator says, over images of the Bush era. "Now we face a choice." http://abcn.ws/R4aFSU

IT'S CHICK-FIL-A DAY, BROUGHT TO YOU BY MIKE HUCKABEE. Yahoo! News' Dylan Stableford reports: "The still-simmering controversy sparked by the Chick-fil-A president's public comments against same-sex marriage is set to reignite this week, as more than 500,000 people say they will join former Arkansas Gov. Mike Huckabee's 'Chick-fil-A Appreciation Day' on Wednesday by 'simply showing up and eating' at one of the company's 1,600 restaurants, while protesters backed by gay and lesbian groups plan to participate in a same-sex 'kiss-in' on Friday at the same stores." http://yhoo.it/T32KbB

NEW ABC/YAHOO! VIDEO: CAN ROMNEY STOP THE GAFFE TRACK? In the latest installment of "Top Line," Yahoo!'s David Chalian and ABC's Rick Klein break down Mitt Romney's gaffe problem and the 2012 race's turn toward the positive in new TV ads from both candidates. Klein: "It almost seems reversed to me ? you start by introducing yourself, then you try to attack, attack, attack-it seems like we went to the attack part first." Chalian: "[Romney] comes back, turns the page, there's the bio push with the new ad, there's the VP rollout, there's the convention, and I think they're going to start doing sort of a three-dimensional Mitt Romney." http://yhoo.it/M3l3Nr

HOW OBAMA RATES IN SWING STATES. Thirteen states gave President Obama an approval rating of over 50 percent in the first half of 2012, while 16 delivered ratings of under 40 percent, according to a new state-by-state data from Gallup. Obama is most popular in D.C. (83 percent approval) and Hawaii (63 percent); he's least popular in Utah (26 percent) and Wyomong (28 percent). Here's how the president fared in swing states: Florida (46 percent), Virginia (46 percent), Pennsylvania (46 percent), Nevada (45 percent), North Carolina (45 percent), Ohio (44 percent), Colorado (43 percent), New Hampshire (43 percent). http://bit.ly/M3gMtp

ROMNEY MEETS WITH GOP MONEY MEN. Politico's Kenneth P. Vogel and William Bergsrtom report: "Mitt Romney will hold a fundraiser with some of the biggest donors in GOP politics in Aspen on Thursday night on the sidelines of a closed-door Republican Governors Association high-rollers event, sources tell POLITICO. After attending public events during the day at the Jefferson County Fairgrounds and Basalt High School, Romney plans to join mega-donors in town for a retreat hosted by the RGA's so-called Executive Roundtable program, which will draw some of the biggest names in GOP politics, including several high-powered governors, a top adviser to Romney, Karl Rove, and other representatives of deep-pocketed political spenders, including a top lieutenant of the Koch brothers." http://politi.co/MYN2NG

ROMNEY OP-ED: 'CULTURE DOES MATTER.' After offending Palestinian officials with his comment about economic disparity and culture, and after later saying he hadn't spoken about Palestinian culture specifically, Mitt Romney last night posted an op-ed at National Review's The Corner, entitled "Culture Does Matter": "In some quarters, that comment became the subject of controversy. But what exactly accounts for prosperity if not culture? In the case of the United States, it is a particular kind of culture that has made us the greatest economic power in the history of the earth. Many significant features come to mind: our work ethic, our appreciation for education, our willingness to take risks, our commitment to honor and oath, our family orientation, our devotion to a purpose greater than ourselves, our patriotism. But one feature of our culture that propels the American economy stands out above all others: freedom." http://bit.ly/Naj8Tn

A PARTING GAFFE? ROMNEY PRAISED ISRAELI HEALTH SYSTEM. The Boston Globe's Matt Viser writes: "'We have to find ways, not just to provide health care to more people, but to find ways to finally manage our health care costs,' Romney said during the fund-raiser at the King David Hotel in Jerusalem. Romney's praise for Israel's health care system was greeted with some surprise. 'We're laughing - for a Republican to praise the Israeli health care system, which is managed care, universal coverage, with no small amount of federal government control and oversight,' said Karen Feinstein, president and chief executive of the Pennsylvania-based Jewish Healthcare Foundation, which has been studying the differences between the Israeli and US health care systems." http://b.globe.com/NIN5yX

ROMNEY TRIES TO TURN THE PAGE WITH PRESS. After one of his traveling press aides told reporters to "kiss my a**" at a Polish holy site, The Hill's Amie Parnes and Justin Sink report that the campaign will reset its media strategy: "Mitt Romney's presidential campaign is promising to become more media-friendly after headlines during the Republican candidate's weeklong foreign trip highlighted an increasingly fractious relationship with the press. Fewer than 100 days out from the election, the campaign is expected to provide more press briefings and heightened access to the candidate in the coming days, and to make changes to the travel pool that will make it more media friendly." http://bit.ly/QdN0T6

BY THE NUMBERS: WHO'S MORE ACCESSIBLE? ABC's Shushannah Walshe writes: Obama has held five press availabilities plus answered shouted questions from the press during at least two other White House events, equaling seven times. Romney's number is similar. He's held eight press conferences since Santorum got out of the race. http://abcn.ws/Qv4Pzq

CHECK YOUR MAIL: SOME WILL GET HEALTH INSURANCE REBATES. ABC's Julie Percha reports: A new provision of the Affordable Care Act - called the Medical Loss Ratio, or the "80/20? provision - could mean some Americans will see a rebate from their health insurance companies tomorrow ? Under the law, small-group and individual-plan insurance companies that annually spend less than 80 percent of premium dollars on medical care owe their customers a rebate. For insurers to large businesses, the percentage split is 85-15. http://abcn.ws/Plqvqw

USPS TO DEFAULT ON TREASURY PAYMENT. The Washington Post's Lisa Rein and Ed O'Keefe report: "The U.S. Postal Service, facing a $14.1 billion loss this fiscal year amid plummeting mail volume, will default for the first time Wednesday, on a congressionally mandated $5.5 billion payment to the U.S. Treasury. Postal officials said Monday that without close to that sum in the bank, they can't make the payment, which is part of a 10-year plan to set aside health benefits for retired postal workers." http://wapo.st/Qv2XGZ

HARRY REID SPECULATES WILDLY ABOUT ROMNEY'S TAXES. ABC's Sunlen Miller reports: Here's a totally unsubstantiated rumor: Senate Majority Leader Harry Reid, D-Nev., said that he's heard that Romney did not pay any taxes for 10 years. ? In an interview with the Huffington Post , Reid said that a month ago someone who invested with Bain Capital, called his office to say that Romney, "didn't pay any taxes for 10 years." ? "He didn't pay taxes for 10 years! Now, do I know that that's true? Well, I'm not certain," said Reid. "But obviously he can't release those tax returns. How would it look?" http://abcn.ws/R7HAug

PFEIFFER APOLOGIZES TO KRAUTHAMMER. ABC's Mary Bruce reports: "On Friday, Pfeiffer slammed Krauthammer for repeating "this ridiculous claim" that President Obama had removed the bust of Winston Churchill from the Oval Office and sent it back to the British Embassy. It was later discovered, as Jake Tapper reported, that there are actually two Winston Churchill busts ? "I take your criticism seriously and you are correct that you are owed an apology," Pfeiffer wrote Krauthammer. "There was clearly an internal confusion about the two busts ?" http://abcn.ws/NamBRW

CALLISTA GINGRICH'S ELEPHANT IS BACK. Politico's Ginger Gibson reports: "Ellis the Elephant will soon be making a return to book shelves. Callista Gingrich, wife of failed presidential candidate and former House Speaker Newt Gingrich, is releasing a sequel to her book featuring the time-traveling title character, her publisher Regnery confirmed. 'Land of the Pilgrims Pride: Ellis Discovers the 13 Colonies' is set to release in October. The first book, 'Sweet Land of Liberty,' followed Ellis the Elephant as he traveled through time to learn about American history." http://politi.co/NIPQjG

REID, BOEHNER STRIKE 6-MONTH DEAL TO FUND GOVERNMENT. ABC's John Parkinson and Sunlen Miller report: "We've got an agreement," Senate Majority Leader Harry Reid, D-Nev., said Tuesday following the Democrats weekly caucus lunch. "This is very good, because we can resolve these critical issues that directly affect the country soon as the election's over and move on to do good things. It puts this out of the way, and that's very important." Congress will not pass the legislation before the August recess, but leaders said they expect to vote on it shortly after returning from a five-week recess September 10. http://abcn.ws/T32ut5

VEEP BEAT:

with ABC's Arlette Saenz ( @ArletteSaenz)

-FORMER BUSH SPEECHWRITER PUSHES PAUL RYAN: Marc Thiessen, a former speechwriter for President George W. Bush, wrote Tuesday that Romney needs to select a runningmate like Dick Cheney, suggesting that Rep. Paul Ryan would fit the mold. "That is precisely what Mitt Romney needs: someone who, like Cheney, is seen by conservatives as one of their own, and, like Cheney, will be taken seriously from the get-go as a potential president of the United States," Thiessen wrote. "But Romney also must shore up his right flank, and generate enthusiasm for his ticket that is currently lacking with the GOP's conservative base. He needs a pick who will give conservatives a reason to vote for the Romney ticket and not just against Obama-Biden. So the question for him becomes, is there anyone among the current vice presidential contenders who can meet both tests? One obvious choice here is Paul Ryan. Ryan is serious, substantive - wonky, even - and is clearly ready for the presidency." http://bit.ly/OISDYy

-McDONNELL: 'I LOVE CHICKEN' Virginia Gov. Bob McDonnell waded into the Chick-Fil-A controversy Tuesday, saying people should be allowed to open and grow businesses regardless of their political beliefs and also declared his affection for chicken, WTOP's Paul Shinkman reported. "The governor of Virginia became the latest politician to offer his perspective on a controversy that could banish Chick-Fil-A from jurisdictions nationwide," Shinkman wrote. "When asked about the backlash stemming from the fast food restaurant's public opposition to gay marriage, Gov. Bob McDonnell said, 'I love chicken.' Following a pause, the governor continued: 'If we start having governments issue permits or zoning changes, or withholding those because of someone's political or religious beliefs, we are going down a very bad road.'" http://bit.ly/OITOaa

WHO'S TWEETING?

NEW: @RomneyResponse : Follow @RomneyResponse for the latest on @BarackObama's failed record, his campaign's false attacks, and our response.

@jaketapper : RIP Gore Vidal. I interviewed him 12 years ago > http://www.salon.com/2000/09/20/vidal_5/ ? Quite an experience!

@HuntsmanAbby : Half of the American people have never read a newspaper. Half never voted for president. One hopes it is the same half->Gore Vidal

@jonward11 : my guess is the Romney "ad" on auto bailouts is a head fake, but it certainly got Chicago to jump http://huff.to/PlwRpK

@ckanal : 5 must-watch #olympics events today, August 1 http://huff.to/NIBMqp via @HuffPostSports

POLITICAL RADAR

-President Obama hits the campaign trail in Mansfield and Akron, Ohio holding two grassroots events in the battleground state. First Lady Michelle Obama will also leave the White House for the day speaking at two campaign events in Greensboro and Raleigh, North Carolina.

-Mitt Romney is back in Boston, Massachusetts after his foreign trip and has no campaign events scheduled.

-On the Veepstakes front, Chris Christie, Nikki Haley, Bobby Jindal, and Bob McDonnell are all in Aspen, CO taking part in a conversation at the Aspen Institute.

ABC's Josh Haskell ( @HaskellBuzz)

Check out The Note's Futures Calendar : http://abcn.ws/ZI9gV

Also Read

Source: http://news.yahoo.com/texas-toast-tea-party-candidates-win-means-washington-125052347--abc-news-politics.html

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Scientists discover molecular link between circadian clock disturbances and inflammatory diseases

Scientists discover molecular link between circadian clock disturbances and inflammatory diseases [ Back to EurekAlert! ] Public release date: 1-Aug-2012
[ | E-mail | Share Share ]

Contact: Andy Hoang
AHoang@salk.edu
619-861-5811
Salk Institute

Finding may lead to new treatments for diabetes, obesity and other chronic diseases

LA JOLLA, CA ---- Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.

Researchers at the Salk Institute for Biological Studies have now found a possible molecular link between circadian rhythm disturbances and an increased inflammatory response. In a study published July 9 in Proceedings of the National Academy of Sciences, the Salk team found that the absence of a key circadian clock component called cryptochrome (CRY) leads to the activation of a signaling system that elevates levels of inflammatory molecules in the body.

"There is compelling evidence that low-grade, constant inflammation could be the underlying cause of chronic diseases such as diabetes, obesity and cancer," says senior author Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science. "Our results strongly indicate that an arrhythmic clock system, induced by the absence of CRY proteins, alone is sufficient to increase the stress level of cells, leading to the constant expression of inflammatory proteins and causing low-grade, chronic inflammation."

Cryptochrome serves as a break to slow the circadian clock's activity, signaling our biological systems to wind down each evening. In the morning, CRY stops inhibiting the clock's activity, helping our physiology ramp up for the coming day.

To gain insight into the role of circadian clock components on immune function, the Salk scientists measured the expression of inflammatory mediators in the hypothalamus (the area of the brain responsible for sleep-wake cycle regulation) of mice with deleted CRY genes. Through a variety of tests, these knockout mice showed a significant increase in the expression of certain inflammatory proteins known as cytokines, including interleukin-6 and tumor necrosis factor-?, compared to mice with CRY genes.

"Our findings demonstrate that a lack of cryptochrome activates these proinflammatory molecules, indicating a potential role for cryptochrome in the regulation of inflammatory cytokine expression," says Satchidananda Panda, an associate professor in Salk's Regulatory Biology Laboratory and one of the senior authors of the study.

In addition, the researchers found that a lack of CRY activated the NF-kB pathway, a molecular signaling conduit that controls many genes involved in inflammation. NF-kB is a protein complex in a cell's cytoplasm, "just happily doing nothing," says Verma. In response to stimuli, it is transferred to the cell's nucleus, where it binds to inflammation genes and turns them on. The regulation of these genes is tightly controlled, but NF-kB does not completely shut off their expression. This lingering expression causes inflammation.

"Every time this pathway is turned on, there is a residual amount of inflammation left in the body," says Rajesh Narasimamurthy, a research associate in Verma's laboratory and the paper's first author. "That adds up over time, contributing to inflammation-related diseases like obesity and diabetes."

Previous research has shown that suppressing the activity of the NF-kB pathway might be a suitable therapy for some diseases. For example, NF-kB is activated automatically in cancer cells of multiple myeloma, which affects infection-fighting plasma cells in the bone marrow and allows the cells to proliferate. Drugs that inhibit this activity might be able to degrade NF-kB to the point that it may kill off the disease.

The researchers say the goal now is to find out how to suppress NF-kB activation in the short term to treat diseases like diabetes. They caution that any long-term suppression of the pathway could lead to chronic infection. "We would like to find molecules that modify this activity and focus on those small-molecule inhibitors to treat disease," Verma adds.

###

Other researchers on the study were Fei Liu, of Salk's Laboratory of Genetics, and Megumi Hatori and Surendra K. Nayak, of Salk's Regulatory Biology Laboratory.

The work was supported by the National Institutes of Health, the National Institute of Allergy and Infectious Diseases, Ipsen/Biomeasure, Sanofi-Aventis, the H.N. and Frances C. Berger Foundation, the Swiss National Science Foundation and the Japan Society for Promotion of Science.

About the Salk Institute for Biological Studies:

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.



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Scientists discover molecular link between circadian clock disturbances and inflammatory diseases [ Back to EurekAlert! ] Public release date: 1-Aug-2012
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Contact: Andy Hoang
AHoang@salk.edu
619-861-5811
Salk Institute

Finding may lead to new treatments for diabetes, obesity and other chronic diseases

LA JOLLA, CA ---- Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.

Researchers at the Salk Institute for Biological Studies have now found a possible molecular link between circadian rhythm disturbances and an increased inflammatory response. In a study published July 9 in Proceedings of the National Academy of Sciences, the Salk team found that the absence of a key circadian clock component called cryptochrome (CRY) leads to the activation of a signaling system that elevates levels of inflammatory molecules in the body.

"There is compelling evidence that low-grade, constant inflammation could be the underlying cause of chronic diseases such as diabetes, obesity and cancer," says senior author Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science. "Our results strongly indicate that an arrhythmic clock system, induced by the absence of CRY proteins, alone is sufficient to increase the stress level of cells, leading to the constant expression of inflammatory proteins and causing low-grade, chronic inflammation."

Cryptochrome serves as a break to slow the circadian clock's activity, signaling our biological systems to wind down each evening. In the morning, CRY stops inhibiting the clock's activity, helping our physiology ramp up for the coming day.

To gain insight into the role of circadian clock components on immune function, the Salk scientists measured the expression of inflammatory mediators in the hypothalamus (the area of the brain responsible for sleep-wake cycle regulation) of mice with deleted CRY genes. Through a variety of tests, these knockout mice showed a significant increase in the expression of certain inflammatory proteins known as cytokines, including interleukin-6 and tumor necrosis factor-?, compared to mice with CRY genes.

"Our findings demonstrate that a lack of cryptochrome activates these proinflammatory molecules, indicating a potential role for cryptochrome in the regulation of inflammatory cytokine expression," says Satchidananda Panda, an associate professor in Salk's Regulatory Biology Laboratory and one of the senior authors of the study.

In addition, the researchers found that a lack of CRY activated the NF-kB pathway, a molecular signaling conduit that controls many genes involved in inflammation. NF-kB is a protein complex in a cell's cytoplasm, "just happily doing nothing," says Verma. In response to stimuli, it is transferred to the cell's nucleus, where it binds to inflammation genes and turns them on. The regulation of these genes is tightly controlled, but NF-kB does not completely shut off their expression. This lingering expression causes inflammation.

"Every time this pathway is turned on, there is a residual amount of inflammation left in the body," says Rajesh Narasimamurthy, a research associate in Verma's laboratory and the paper's first author. "That adds up over time, contributing to inflammation-related diseases like obesity and diabetes."

Previous research has shown that suppressing the activity of the NF-kB pathway might be a suitable therapy for some diseases. For example, NF-kB is activated automatically in cancer cells of multiple myeloma, which affects infection-fighting plasma cells in the bone marrow and allows the cells to proliferate. Drugs that inhibit this activity might be able to degrade NF-kB to the point that it may kill off the disease.

The researchers say the goal now is to find out how to suppress NF-kB activation in the short term to treat diseases like diabetes. They caution that any long-term suppression of the pathway could lead to chronic infection. "We would like to find molecules that modify this activity and focus on those small-molecule inhibitors to treat disease," Verma adds.

###

Other researchers on the study were Fei Liu, of Salk's Laboratory of Genetics, and Megumi Hatori and Surendra K. Nayak, of Salk's Regulatory Biology Laboratory.

The work was supported by the National Institutes of Health, the National Institute of Allergy and Infectious Diseases, Ipsen/Biomeasure, Sanofi-Aventis, the H.N. and Frances C. Berger Foundation, the Swiss National Science Foundation and the Japan Society for Promotion of Science.

About the Salk Institute for Biological Studies:

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.



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Source: http://www.eurekalert.org/pub_releases/2012-08/si-sdm073112.php

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Wednesday, August 1, 2012

Spanish regions rebel against deficit targets

MADRID (AP) ? A growing number of Spain's regions are rebelling against central government attempts to rein in their spending, threatening the country's efforts to convince investors that it can manage its finances.

A meeting called Tuesday to slash the 17 semiautonomous regions' total deficit to 0.7 percent of Spain's economic output by next year was boycotted by the powerful northeastern region of Catalonia while the chief financial officer for the southern Andalusia left the meeting early in protest.

Two other regions, Asturias and the Canary Islands, voted against the proposal, which was eventually approved by a majority of the regional governments.

Finance Minister Cristobal Montoro warned the regions that the federal government would not tolerate any deviation in the deficit targets. Curbing Spain's central and regional deficits is seen as key to satisfying Spain's 16 euro partners that it is in control of its finances and in bringing down the country's borrowing costs.

"I am not worried because nobody is going to put the deficit at risk," Montoro said. He intimated the regions could be obliged by law to comply.

The rebel regions accuse the central government of being inflexible in maintaining 2012 national deficit targets of 3.5 percent of gross domestic product and 1.5 percent for the regions despite the fact that Spain has been allowed to raise its overall 2012 target of 6.3 percent from the originally agreed 5.3 percent.

Andalusia complains that its finances are in relatively good shape and that such austerity this year and again in 2013 would choke it.

Meanwhile, Catalonia, the region with most debt, said it boycotted the meeting because Montoro was not open to alternative proposals.

This week Catalonia announced that severe cash flow problems meant it won't be able to make July payments to dozens of private social service suppliers including hospitals, child-care centers and retiree homes. The region also admits it may have to join two other regions in tapping a new central government loan fund for cash-strapped regional governments although it denies that this would basically constitute a bailout.

Spain's is in its second recession in three years while its regions and banks have mounting debt and deficits following a real estate crash in 2008. The country has an unemployment rate of nearly 25 percent unemployment and is struggling to avoid having to seek a financial bailout like those sought by Greece, Ireland, Portugal and Cyprus.

The other 16 countries that use the euro have already agreed to lend Spain up to ?100 billion ($123 billion) in loans for its troubled banks. A sovereign bailout for the country, the eurozone's fourth largest economy, would be far costlier and could seriously challenge the eurozone's finances.

U.S. rating agency Standard & Poor's Wednesday acknowledged the Spain's commitment to its austerity and reform measures when it affirmed its credit score at BBB+. However, the agency warned the country could be subject to further downgrades.

The country's Treasury will face a fresh test of investor sentiment Thursday when it auctions bonds maturing in 2014, 2016 and 2022.

The interest rate for Spain's benchmark 10-year bond on the secondary market remained perilously high Wednesday at 6.6 percent. A rate close to 7 percent is deemed unsustainable for a country over the long term.

The financial market pressure has eased on Spain over the past week after remarks from European leaders that they work to help save the euro.

Source: http://news.yahoo.com/spanish-regions-rebel-against-deficit-targets-085443015--finance.html

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NY couple, 85, to remarry 48 years after divorce

Roland Davis and Lena Henderson, both 85, kiss as they pose for a photo in West Seneca, N.Y., Tuesday, July 31, 2012. They got married while still in their teens, divorced 20 years later and are getting remarried on Saturday, August 4, after nearly a half-century apart. (AP Photo/David Duprey)

Roland Davis and Lena Henderson, both 85, kiss as they pose for a photo in West Seneca, N.Y., Tuesday, July 31, 2012. They got married while still in their teens, divorced 20 years later and are getting remarried on Saturday, August 4, after nearly a half-century apart. (AP Photo/David Duprey)

Roland Davis and Lena Henderson, both 85, pose for a photo in West Seneca, N.Y., Tuesday, July 31, 2012. They got married while still in their teens, divorced 20 years later and are getting remarried on Saturday, August 4, after nearly a half-century apart. (AP Photo/David Duprey)

Roland Davis and Lena Henderson, both 85, pose for a photo in West Seneca, N.Y., Tuesday, July 31, 2012. They got married while still in their teens, divorced 20 years later and are getting remarried on Saturday, August 4, after nearly a half-century apart. (AP Photo/David Duprey)

Roland Davis and Lena Henderson, both 85, pose for a photo in West Seneca, N.Y., Tuesday, July 31, 2012. They got married while still in their teens, divorced 20 years later and are getting remarried on Saturday, August 4, after nearly a half-century apart. (AP Photo/David Duprey)

In a Monday, July 23, 2012 photo, Roland Davis of Colorado, left, and Lena Henderson of West Seneca, N.Y. pose for a photo at the Buffalo City Hall. DAvis and Henderson were divorced 50 years ago in Georgia. At 85, they are remarrying. They went to City Hall to get their marriage license,, for their August 4 wedding. (AP Photo/Buffalo News, Sharon Cantillon) (AP Photo/The Buffalo News, ) TV OUT; MAGS OUT; MANDATORY CREDIT; BATAVIA DAILY NEWS OUT; DUNKIRK OBSERVER OUT; JAMESTOWN POST-JOURNAL OUT; LOCKPORT UNION-SUN JOURNAL OUT; NIAGARA GAZETTE OUT; OLEAN TIMES-HERALD OUT; SALAMANCA PRESS OUT; TONAWANDA NEWS OUT

(AP) ? They got hitched while still in their teens, divorced 20 years and four children later, and are getting remarried after nearly a half-century apart.

For Lena Henderson and Roland Davis, both 85 years old, the second time around is finally here. The couple plans to get married again on Saturday, with four generations on hand to see it happen.

"It's every child's dream, every child who has ever been in a family where divorce has occurred, that your parents would come back together," their youngest daughter, Renita Chadwick, said Tuesday as wedding preparations were in full swing.

"We are all so ridiculously excited. We're like little children again," said Chadwick, herself a grandmother.

Henderson and Davis met as teenagers in Chattanooga, Tenn., and were married by a justice of the peace. There was no reception or honeymoon.

"Oh no," Henderson recalled with a laugh. "He went to work and I went home." Davis was a hotel bellhop at the time, about to begin a career in the military.

This time around, a church wedding is planned, at Elim Christian Fellowship Church in Buffalo, followed by a reception at an Amherst restaurant.

Still no honeymoon trip, though.

"I'm just happy that we're here," said Davis, who recently moved to suburban Buffalo from Colorado, where he was living alone following the death of his second wife in January. Henderson also was widowed after re-marrying.

Davis proposed to Henderson over the phone around Easter and she accepted, even though they hadn't seen each other since a family funeral in 1996. Before that, the two hadn't been face-to-face since splitting up in 1964, though they had stayed in touch and kept up with each other's lives through the children.

Their oldest daughter, Johnnie Mae Funderbirk, had been urging her father to return to New York since his wife's death.

Davis was receptive, especially to the idea of reconnecting with Henderson.

"I had always kind of had that in mind, mostly because of the children," he said. "You never forget someone that you cared for at one time or another."

Henderson and Davis both said it was "nice" to see one another again, this time as an engaged couple.

The children are less reserved.

"I'm as excited as some 9-year-old whose parents are getting back together," Funderbirk said, "and I'm 65 years old."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-07-31-Couple-Second%20Time%20Around/id-0741b2902222411e9eded74b34dad3e6

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Speek Disrupts the Communications World With a Revolutionary ...

Let?s get real here: an overwhelming majority of people hate phone calls. In this brave new world of texting, picture messages, and social media, picking up your phone to make an actual phone call is actually one of the more archaic forms of communication. This also hits home on a personal note because much to the chagrin of my counterparts in Boston who we regularly speak with, I think the part I?ve hated the most about communicating with our different editorial teams in the country has been being forced to use awful conference call systems. Between the poor audio quality, being forced to huddle around a single phone like cavemen around a campfire, and the horrendous Kenny G-esque music you?re forced to listen to while you?re put on hold, it?s pretty much one of the things I hate the most about work.?Granted it?s hard to complain about a service that?s essentially free, but the fact of the matter is that nobody has really stepped up to shake up this rather draconic method of communication for conference calls.

That is until now.

Speek?(yes, I spelled it right) is a refreshing take on the concept of conference calls, where as most call websites would make you use a phone number with a corresponding PIN, Speek utilizes a link to your ?call profile? (something like speek.com/carlpierre) so that a simple click can get you started with your phone call. ?From that one link, you can join a call using a normal phone, a laptop, a web browser, SMS, mobile browsers and more. ?You can join the conference call from anywhere in the world, and with the added social media features, share your conference call profile with everybody in your digital network.

Brilliant? You betcha. And here?s a video too.

As if having an amazingly disruptive product wasn?t enough, Speek also boasts an amazing startup team composed of?Danny Boice (Co-Founder, CTO), John Bracken (Co-Founder, CEO), and Virginia Lee (Product Manager). This ace founding team has been able to accomplish a lot in the short span that the startup has been around, including launching a $1 million seed round led by 500 Startups, setting up headquarters in the swanky digs of AOL?s Fishbowl Labs, launching a public beta this past May, and having a rockstar advisory board which include D.C. Tech legends such as Jay Rappaport (first AOL COO, Vonage Pres / COO, Clearslide, ePals) and Minh Nguyen (co-founded Plaxo w/ Sean Parker). Speek has already hit some amazing milestones including reaching over 2 million minutes of voice conference calls to date as well as?boasting thousands of active users for the service which doubles in number every two weeks.

These guys are a big deal, and don?t show any signs of slowing down.

Overall, I can?t wait to see what this amazing team will pull off over the next few months as they continue to grow their round, and I am more than grateful to finally have a nifty product solution to the torturous process of conference calls.

Source: http://inthecapital.com/2012/08/01/speek-disrupts-the-communication-world-with-a-revolutionary-take-on-the-traditional-conference-call/

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